Characterization of the Role of Dopamine in the Primate Substania Nigra


Thyagarajan Subramanian
Emory University

Dr. Thyagarajan Subramanian used his Emory Unviersity's comprehensive animal laboratories to investigate the hypothesis that dopaminergic (DA) neurons in the substantia nigra (SN) not only secrete the chemical in the axonal terminals that end in the striatum, but also in their dendrites (outgrowths) in their own areas. Injections of DA agonists into various areas of two animals' parkinsonian brains showed modest to better reductions of disability when they were behaviorally tested. He is now completing the placebo-controlled portion of his study in order to substantiate his data.

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