Human Brain Expression of Alpha-Synuclein Messenger RNA in Parkinson’s Disease and Related Diseases

Miller, David W., Ph.D.
Massachusetts General Hospital, Boston, MA

The aggregations of the alpha-synuclein protein in brains of patients with PD and several other neurodegenerative disorders have caused the disorders to be termed synucleinopathies. Dr. David W. Miller and his Massachusetts
General Hospital (Boston) group will compare the expression of this gene in brain tissue from each of these disorders with its expression in tissue from healthy brains and also the relative levels of genetic information in the various brain regions that are affected by synuclein. They hope to determine the exactitude of a direct or indirect role for this presynaptic (found in cells before the synapse) protein and whether or not it plays a role in the selective vulnerability of DA neurons in these disorders.